Results of Magnetic Nano-iron Striking Glioma Treatment

Nano-iron, iron magnetic nanoparticles, nano-iron manufacturers

Hyperthermia is a type of glioma using a variety of physical energy (such as microwave, radio frequency and ultrasound) to produce thermal effects in glioma tissues, so glioma tissue temperature reaches 41-43 degrees Celsius effective treatment temperature, and maintain certain period of time (usually 30 minutes), to destroy the tumor cells metabolism, accelerate the apoptosis of tumor cells but not in normal brain tissue without damage methods.

Magnetic nano iron is an alternating magnetic field capable of rapid warming of nanomaterials. Tc is the Curie temperature of a magnetic field in some of the material to non-magnetic critical temperature. When the temperature is less than Tc, the ferromagnetic substance is shown, it is strongly absorbed electromagnetic energy to heat up. When the temperature is higher than Tc, they turned into non-magnetic material, the loss of the ability to absorb electromagnetic energy to heat up. Magnetic nano iron is a material having a lower TC. When the magnetic nano-iron stereotactic injection of rat glioma, due to hysteresis, relaxation effects, the domain wall resonance effect, under the irradiation of an external magnetic field can strongly absorb electromagnetic energy and temperature to 41-43 degrees Celsius, and can steady for 30 minutes, promote tumor cell apoptosis and inhibit the proliferation of tumor, and the smaller surrounding normal brain tissue damage.

At present, although the nano iron hyperthermia glioma impressive results, but overall still in the research stage in vitro and in animal experiments. The modified magnetic iron nanoparticles can cross the blood, after so after intravenous injection, by active and passive accumulation in tumor targeting areas, can greatly improve the tumor area magnetic nano iron concentration, enhance the efficacy and minimize normal tissue injury. Meanwhile, the modified magnetic nanoparticles can carry iron ligand specificity, binding to a specific tumor cell surface receptor, the nano-iron, and precisely to reach the stable area ofa solid tumor stays. Modified nano-iron can also carry chemotherapy drugs, tumor hyperthermia and chemotherapy simultaneously. Magnetic nano iron hyperthermia, chemotherapy, radiotherapy for the treatment of cancer and other comprehensive orientation will become glioma therapy.