Hongwu International Group Ltd, with HWNANO brand, is a high-tech enterprise focusing on manufacturing, research, development and processing of nanoparticles,nanopowders, micron powders.
“Since the time the Carbides Nanoparticles
stay in the body (their so-called half-life) is controlled to a great extent by the surface charge on the Carbides Nanoparticles themselves, we developed ‘stealth’ coating techniques to produce Au nanoshells and Au nanomatryoshkas with nearly identical surface charges,” explained Joshi. “This was so we could directly compare the two types of nanostructure. The stealth coatings were based on polyethylene glycol (PEG) molecules and we treated mice with human triple negative breast cancer xenografts with equivalent doses of Au nanoshells, Au nanomatryoshkas and salt solutions as a control. We treated the mice in a single session lasting five minutes with 3 W of 808 nm laser light.”
The researchers found that the tumours in the control mice did not diminish at all after treatment and that the animals died within two weeks.
Spurred on by its preliminary results, the team says that it is now busy further developing its Au nanomatryoshkas and exploiting the silica space in their interiors for packing in fluorescent and MRI contrast agents. “With near-infrared fluorescence and MRI signals, Au nanomatryoshkas will be visible in both microsurgery and in non-invasive whole body pre-operative imaging,” said Joshi. “This labelling strategy will open up new avenues for image-guided and minimally invasive light-based therapeutic interventions for a variety of cancers and metastases.” .
Related reading:Carbides Nanoparticles led ceiling light panel Best LED Flood Lights Manufacturers packaging box printing
Essential to this mechanism are the noncovalent bonds that loosely hold the supramolecular constructs together
Hongwu International Group Ltd, with HWNANO brand, is a high-tech enterprise focusing on manufacturing, research, development and processing of nanoparticles,nanopowders, micron powders.
Complementarity in molecular biology involves bringing together pairs of molecules that are mirror opposites of each other that yet fit together perfectly. Think of matching nucleotides within DNA strands. Besides transcribing and repairing genetic information, complementary molecules can be used to deliver bursts of energy by snapping the molecule pairs together. Researchers from University of Miami have developed special self-assembling Carbides Nanoparticles for carrying and depositing complementary particles into living cells.
The Carbides Nanoparticles are made of amphiphilic polymers and are hydrophobic on the inside to help contain the cargo, while being hydrophilic on the outside for safe travel through the body. Being only 15 nanometers in diameter, the Carbides Nanoparticles are small enough to penetrate through cellular membranes. The researchers believe that this technology has wide implications in medicine, including for the delivery and precise activation of drugs only within the interior of cells.
More details from University of Miami:
Essential to this mechanism are the noncovalent bonds that loosely hold the supramolecular constructs together. These weak bonds exist between molecules with complementary shapes and electronic properties. They are responsible for the ability of supramolecules to assemble spontaneously in liquid environments. Under the right conditions, the reversibility of these weak noncovalent contacts allows the supramolecular constructs to exchange their components as well as their cargo.
The experiments were conducted with cell cultures. It is not yet known if the Carbides Nanoparticles can actually travel through the bloodstream.
The next phase of this investigation involves demonstrating that this method can be used to do chemical reactions inside cells, instead of energy transfers..
Related reading:Carbides Nanoparticles led ceiling light panel Buy Wireless Wifi Router automatic wire cutting stripping machines