The biomedical field is a brand-new research field formed by integrating the methods and theories of medicine, biology and other related disciplines. Its research contents include bio-medicine, clinical applied chemistry, cytology and immunology, etc. With the rapid development of technology, many cutting-edge research and inventions in hot areas have played an important role in the field of bio-medicine, such as digital holography, virtual reality, and nanotechnology. It can be said that bio-medicine is an important area related to human beings. Studies have shown that surface-modified nano-gold particles can play a very important role in cell imaging, drug carriers, and many other aspects, its performance is closely related to the structure of nano-gold composition, morphology, size and size. More attention is paid to the appearance of gold nano structures such as rods and spheres.
Nanomaterials are materials in which at least one dimension in the three-dimensional space is in the nanoscale range or consists of them as basic units. Nano gold is a kind of nano material and is a gold nano particle with a diameter of 1-100nm. Nano-gold particles play an important role in molecular detection, photo-thermal therapy, tumor diagnosis, and green catalysis. In the following, I will give a detailed review of the field of bio-medicine.
- Application in bio-moleculardetection and identification
The emergence of nano gold immunolabeling technology in 1971 made it possible to see the great potential of nano gold as an immunological marker. After decades of continuous development, the immunolabeling technology using nanogold as a marker has basically matured. Has become one of the four major immunolabeling technologies. With the advancement of science and technology, people have a deeper understanding of the physicochemical properties of Gold nanoparticles dispersion , thus further expanding the biometric detection technology using nano gold as a marker. At present, nanogold is mainly used in biological detection to detect nucleic acids and proteins. Based on its unique surface plasmon resonance effect, catalytic properties, and high-density properties and other physicochemical properties, nano gold has unparalleled advantages in other areas of biological detection, and it has great potential for early diagnosis of tumors.
- Application in cell imaging and photothermotherapy
The strong scattering of nano gold particles was first used by researchers in the field of nano gold cell imaging and is still the most commonly used nano gold cell imaging method. As long as the diameter of the nano gold particles is greater than 20nm, it can be easily observed in a dark field scattering microscope. Compared with common fluorescent groups, nano gold particles can stably scatter light for a long time without being bleached. At the same time, due to the surface plasmon resonance effect of the nano-gold particles, the molecular electromagnetic field signal will be enhanced if it is within the nano gold surface or within 10 nm from the nano gold surface. Through the extraction of these enhanced electromagnetic field signals, Can be applied to bio-imaging technology. Because nano gold’s two-photon luminescence imaging technology has a much higher signal-to-noise ratio than dark-field microscopy, it has a very high potential for intracellular imaging. In addition, nano-gold particles can produce high thermal behavior by absorbing near-infrared light, a feature that makes it play a significant role in photothermal therapy in medicine.
- Application in drug delivery and controlled release
The specific surface area of nano gold is relatively large, and its surface is easily modified. The drug can easily bind to the nano gold surface after chemical bonds and non-chemical bonds, thereby forming a nano gold drug-loading system. The drug-loading system formed by nano gold has the characteristics of increasing drug solubility, increasing cytotoxicity, and increasing drug stability. Currently, nano gold has been widely used in various fields of bio-medicine as a carrier for various types of drugs. The use of nano gold as a drug carrier can both protect the drug, increase the activity of the drug, reduce the amount of the drug used, and reduce the medical cost.
Related Tags: Nano gold colloid Nano Gold dispersion