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Nano Diamond Powders for Drug Delivery Applications

Diamond is the hardest substance in the world. Mention it, people often associate it with super hard materials, jewelry and industrial diamond drill bits, grinding wheel. But scientists used the characteristics of nano diamond to delivery successful treat leukemia drug to the pathological cells for malignant tumor treatment.

the new scientific research using nano diamond powders technology has solved the difficult that the tumor cells to discharge the treatment drug to cells in vitro, especially in the process of chemotherapy, the diseased cells resistant, this has been a difficult for the doctors.
The research is published in Nanomedicine: Nanotechnology, Biology
Problem: leukemia cells drug resistance

Daunorubicin is a common drug for leukemia treatment, which treat the illness by slowing down and prevent the growth and proliferation of tumor cell, and eventually kill the diseased cells. But in the process of treatment pathological tumor cells is easy to produce resistance phenomenon to daunorubicin.

Nano diamond intervention therapy

At present, the way that the medical community solve drug resistanc is to develop antibody, but more clinical trials show drug toxicity is big and the effect is not obvious.

In view of this, NUS and UCLA researchers have begun to break through the train of thought, to treat particle size only 2 ~ 8 nm nano diamond powders.

Researchers fix soft erythromycin on the surface of nano diamond, and then put the mixture to diseased cells. The results showed that the nano diamond would be able to bring soft erythromycin into cells and cells haven’t been discharged as before, so as to solve the problems of the diseased cells resistance. Because of nanometer size diamond non-invasive and unique surface features, diamond particles can easily be released into the blood vessels and not causing blocked blood vessels at the same time.

Dr Chow said: “the intervention of nanodiamond greatly improve the possibility of biological adaptability and tolerance combining, and to enhance curative effect. at present, in vivo and in vitro drug safety test results show that the drug with medicinal properties is better, this laid a good foundation for further.

Professor DeanHo added: nano diamond is a very promising treatment carrier on medical research. At present, we will further determine which drugs can be hold by nanometer diamond for specific disease treatment, so as to maximize implement the welfare to patients.
Hongwu International Group Ltd is a collectivize technology company, which is professional manufacturer and supplier for nano carbon series powders including nano diamond powders in small quantity for researchers and in bulk order for industry groups.

Our nano diamond powders size includes <10nm, 30-50nm, 80-100nm, grey powder.
our price is very competitive,espeicially in bulk.

If you’re interested in our nano diamond powders, pls feel free to contact us at hwnano@xuzhounano.com. Thank you!

 

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Research progress of Tungsten carbide cobalt thermal spraying powders and coating

In recent years, the research of the tungsten carbide cobalt thermal spraying with nanostructure coatings become the new trend. as a wear resistant coating, due to its good the hardness and toughness, it is widely used in aerospace, metallurgy, machinery fields. Relative to the hard chromium plating, thermal spraying tungsten carbide cobalt ceramic coating have obvious advantages on abrasion resistance, corrosion resistance, fatigue resistance, what’s more, it have fast preparation speed, low cost, good environment. in some application areas, such as aircraft landing gear, the thermal spraying WC2CoCr coating is replacing hard chrome plating.

Nano structure tungsten carbide cobalt thermal spraying powders preparation from Hongwu nanometer:

1. the precursor solution preparation with soluble salt containing tungsten, cobalt mixing chemical composition.mix them evenly, spray drying, roasting, reduction and carbonization.getting Nanocrystalline WC-Co composite powders;
2. nano structured WC-Co composite powders composition can be adjusted according to the using needs,such as adding some other alloying elements growth inhibitor, and the elements content can be accurately controlled.
3. nano WC-Co composite powders, grain size of WC phase is 60nm with low content of impurities.
4. product technology processes mature sound, own a full set of equipment, low cost, large output, high cost performance.
WC-CO nanoparticles introduction form Hongwu nanometer
1. Particle size:60nm
2. Purity:>99%
3.High hardness
4.High-wearing
5.Ratio: WC:Co=88:12/90:10/94:6, namely, WC-12CO,WC-10CO,WC-6CO
6: Property: High hardness & high-wearing–Tungsten Cobalt alloy nanoparticle have good properties of hardness, strength, high breaking and beating ductility as well as high electrical and thermal conductivity.
The phase composition of the thermal spraying wc-co powder effect on the properties of the coating
high cobalt content in the coating can increase the impact toughness of the coating, its bond strength is also good, and not easy to decarburization, able to work under high temperature without lubrication conditions, and have high abrasion resistance and corrosion resistance.The explosion spraying high cobalt content of cobalt coating tungsten carbide (WC225 % Co) coating applied to aeroengine nozzle, can work long-term reliably under 500 ℃.
Clients application case 1
Low temperature supersonic spraying technology, adopting nano structured WC-Co alloy strengthening coating layer surface, it is not only wear-resistant, corrosion-resistant, but surface smooth level off, structure Compact, high bonding strength with matrix.
Clients application case 2
Nano WC-Co composite powders is successfully used in microbit of PCB, and wear experiments show that  the wear rate with the nanometer WC-Co composite powder is lower 30-40% than the standard microcrystalline drilling bit, its life span is about 2.9 times that of the standard drill.
Tungsten is main raw materials preparation nanometer WC-Co composite powders, in the world only China tungsten resource is rich, about 52% of the world’s total reserves, this is the most advantageous conditions to our company research for researching and development nanometer WC-Co composite powders and alloy. All in all, nanometer WC-Co composite powder has immeasurable potential market.

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HongWu nano tungsten carbide cobalt parameters

Carbide is an excellent tool and structural materials, which are extremely versatile, involving almost all areas of the various sectors of the national economy and modern technology. It is estimated that in 2000 the world’s total production of 42,000 tons of carbide, trade in more than 10,000 tons, trade volume reached $ 10 billion. WC-Co is one of the largest output, the most widely used of a class of carbide, the annual market demand worldwide in more than 20,000 tons. Only cutting tools, more than $ 2 billion demands around the world each year..
Currently, the USA Company has been successful production of printed circuit boards with micro drill empty Nanocrystalline WC-Co composite powder and wear experiments show that: the use of nano-WC-Co composite powder prepared drill bit wear rate is 30%-40% lower than the standard microcrystalline, its life is about 2.9 times than the standard drill. According to Japanese industry statistics, computer circuit board processing industry, this year would be required carbide twist drill 60 million (about 180 million), the demand for the world’s nearly 400 million annually, and with the rapid development of technology of microelectronics and information, the market showed a rising trend. In addition to the preparation of micro-drill, the nano-composite powders as well as wide range of applications, including a variety of cutting tools, rock drilling teeth, mold, wear-resistant parts, bearings as well as special-purpose tools. Among these tools, only the preparation of nanocomposite powders used in order to maintain their sharp cutting edge.
New research shows that: nano-WC-Co composite powder used as a wear-resistant coating material shows very good results, the use of rapid melting, thermal spray coating technology to prepare for rapid cooling, making nano-structural properties of the powder is maintained, thereby significantly carbide wear-resistant coating to improve the performance. University of Connecticut Dr.Maurice Gell led by a team of university, industry, research institutions and naval coalition of scientists and engineers have huge research team, Office of Naval Research Science and Technology Affordability Initiative and DODDual Use S & T Program support, is working to nano-WC-Co powders for thermal spraying ships, aircraft and army vehicles.
Tungsten is the main raw material for the preparation of nano-WC-Co composite powder, is a rare metal. Only the world’s rich Chinese tungsten ore resources, about 52% of the world’s total reserves, accounting for 25% of Western developed countries, the United States accounted for only 5.9 percent, more than one hundred other countries split the remaining 17.1% of tungsten ore reserves. Undoubtedly, this is the most favorable conditions for our basic research and development of nano-WC-Co composite powder and alloys. As of 1998, China’s annual output reached 7,000 tons of carbide, tungsten metal production accounts for 76% of world production, tungsten exports about 80% of the international market, ranking first in the world. However, a long time, we only cheap exports of tungsten and tungsten ore resources of primary products, but never in Western Europe, Japan, the United States and other countries import large quantities of carbide deep-processing products.

HongWu nano tungsten carbide cobalt parameters are as follows:
Composite powder ratio is: WC-CO 90/10, 88/12, 94/6
Purity more than 99%, an average particle size of 200nm, grain size less than 50 nm
C is less than 0.09% of free oxygen content of less than 0.25%, the remaining content of less than 0.4% of impurities

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Lithium-ion battery anode material — Silicon Nanopowder

Keywords: silicon nanopowder, nano silicon powder, Si, lithium-ion battery; anode material; nano-composite films

Lithium-ion batteries have high voltage, high specific energy, no memory effect, no pollution, etc., has become one of the main choice of green cells in the 21st century. Currently lithium-ion battery anode material is mainly used commercial carbon-based anode material, but only a theoretical capacity of 372 mAh carbon Kuang 1, unable to meet the next generation of new lithium-ion battery cathode material for high-capacity requirements. Therefore, the development of new non-carbon anode materials is of great significance for the development of lithium-ion batteries.

On this point, after years of painstaking Hongwu Nano graduate output nanometer particle size at 30-50 nm, 99% purity nano-silicon powder, the powder as the anode material for lithium-ion batteries to replace traditional graphite materials. Pilot test of our customers have successfully proven silicon metal nanopowders has good capacity performance, is now 3-5 times graphite products.

Characteristic of lithium-ion battery:
Compared with other secondary batteries, lithium-ion battery has the following advantages:
1. Open circuit voltage is high. Currently, the commercialization of lithium-ion battery platform is up to 3.6-3.7 V, triple nickel-cadmium and nickel-hydrogen batteries. Thus the need for high voltage use of the occasion, the number of batteries connected in series with a lithium-ion battery needs a small, space utilization, small mutual influence between the battery, such as a mobile phone using single cell lithium-ion battery is enough, if NiMH battery requires three electrochemical properties very similar to single cells in series, for use in the process of charging and discharging, the battery due to the electrochemical properties of the three can not be completely the same and thus influence each other, reducing their life.
2. High energy density. Currently the energy density lithium-ion polymer battery made ​​up to 190 Wh Kg-1, 380Wh L. 1, is approximately four times the nickel-cadmium batteries, nickel-hydrogen battery is about twice the.
3. Can be large current charge and discharge, can fully meet the power requirements of cameras and other equipment.
4. A substantial increase in safety performance than lithium batteries, long cycle life. Lithium-ion battery using a lithium intercalation compound as the negative electrode, the discharge to avoid the formation of lithium dendrites, the battery safety performance is significantly improved. In the electrochemical reaction, the electrolyte does not participate in the reaction, Li + is embedded between the positive and negative deintercalation, such as concentration cell, it is called rocking chair battery, so a relatively long cycle life, up to 1200, far more than the nickel-cadmium batteries and nickel-hydrogen batteries.
5. Self-discharge. Month self-discharge is less than 10%, less than 20% of nickel-cadmium batteries, nickel-hydrogen battery to 30%. In the first lithium ion battery during charging the carbon negative electrode surface is formed in the solid electrolyte layer of the intermediate phase (SEI film), which allows ions to pass through, but does not allow the electron passage, it can better prevent self-discharge.
6. No memory effect, environment-friendly. Lithium ion secondary battery does not contain lead, cadmium, mercury and other toxic substances, environmental pollution is a very small system.
In summary, the lithium-ion battery has excellent overall performance. Lithium-ion batteries are mainly used in small mobile electronic devices. With the developing of technology, lithium ion battery as battery could be used in electric vehicles.